Social & Life Sciences

AI in healthcare now aims to improve the effectiveness of treatments, reducing costs and increasing the validity of healthcare. The FDA approves high-speed AI software for clinical imaging and diagnosis. For instance, the DeepMind and IDx-DR TN software are already used to diagnose eye diseases more effectively.

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find the relation of BDNF with other signaling pathways and cellular processes including autophagy, mTOR pathway, progranulin (PGN), and α-Synuclein (α-Syn) which negatively and positively regulate BDNF/tyrosine kinase receptor B (TrkB) signaling pathway.

While several attempts at reducing AD severity have already been presented, mainly targeting symptomatic treatment, there is still no holistic therapy that can effectively reverse AD. For many scientists and pharmaceutical companies, there are several different treatment approaches like cholinesterase inhibitors, NMDA receptor antagonists, b-secretase inhibitors, c-secretase inhibitors, a-secretase stimulators, tau inhibitors, immunotherapy, nutraceuticals, and nanodrugs even though the more secure solution seems to be the early diagnosis of brain lesions, pathophysiological alterations and obvious the case of early and secure prediction.

he actual etiology of Alzheimer’s disease (AD) is still unclear, while several risk factors have been recognized to affect the early onset and progression of the disease catalytically. According to the latest studies, AD can be categorized into eight different categories according to risk factors, symptoms, and pathophysiological lesions.