• While several attempts at reducing AD severity have already been presented, mainly targeting symptomatic treatment, there is still no holistic therapy that can effectively reverse AD. For many scientists and pharmaceutical companies, there are several different treatment approaches like cholinesterase inhibitors, NMDA receptor antagonists, b-secretase inhibitors, c-secretase inhibitors, a-secretase stimulators, tau inhibitors, immunotherapy, nutraceuticals, and nanodrugs even though the more secure solution seems to be the early diagnosis of brain lesions, pathophysiological alterations and obvious the case of early and secure prediction.